Read about the possible side effects of RYDAPT.
For U.S. Residents Only
How to Take Treatment
Your doctor will tell you how to take RYDAPT
RYDAPT® (midostaurin) capsules is a prescription medicine taken by mouth two times a day with food. For acute myeloid leukemia (AML), RYDAPT is taken in addition to chemotherapy. You should always take RYDAPT exactly two times a day as your doctor tells you.
AML treatment usually starts in the hospital. This first phase of treatment is called induction therapy. If the disease is still in your body after the induction phase, your doctor may give you additional treatment. This second phase of treatment is called consolidation therapy. This treatment can be given while you are in the hospital or as outpatient therapy. Your doctor will discuss what the best treatment plan for you may be.
INDUCTION (1 to 2 cycles*)
Chemotherapy: Days 1 to 7
Because AML is a disease that can get worse quickly, it’s important that you start treatment for AML right after your diagnosis. This initial stage of treatment, which is given during your stay in the hospital, is called induction therapy and will most likely include chemotherapy. The goals of induction therapy are to:
- Kill as many AML cells as possible
- Get blood counts back to normal
- Get rid of all signs of the disease for an extended period of time
During your induction with chemotherapy as part of the diagnostic workup, you may be tested to determine your FLT3 status.
RYDAPT: Days 8 to 21
If you have tested positive for FLT3 and your health care provider has prescribed RYDAPT, you will receive it following the first 7 days of induction chemotherapy treatment.
CONSOLIDATION (up to 4 cycles)
Chemotherapy: Days 1, 3, and 5
Because there may be AML cells remaining after the first phase of your treatment (the induction phase), you may need additional therapy. This may include additional rounds of chemotherapy, which can be given while you are in the hospital or as outpatient therapy. Your doctor will discuss what the best treatment plan for you may be.
RYDAPT: Days 8 to 21
Similar to the induction phase, you may receive RYDAPT following your consolidation chemotherapy treatment.†
Have a look at our list of questions you could ask your doctor.
*The number of induction cycles is based on the clinical trial. Your health care provider may choose to adjust this number depending on your individual treatment plan.
†In a clinical study, RYDAPT was given on Day 8 of treatment following chemotherapy.
During your stay in the hospital, your health care team will give you RYDAPT in addition to your regular chemotherapy.
Your doctor will likely begin to give you RYDAPT the day after your first 7 days of induction chemotherapy.
How often do I take RYDAPT?
Capsules not actual size.
Your doctor will tell you how many capsules of RYDAPT you need to take. The usual starting dose is 2 capsules twice a day. These should be taken about 12 hours apart (with breakfast and with dinner).
Taking RYDAPT at the same time each day will help you to remember when to take your medicine.
Your doctor may tell you to decrease your dose, temporarily stop, or completely stop taking RYDAPT if you develop certain side effects during treatment with RYDAPT. Do not change your dose unless your doctor tells you to.
Tips for taking RYDAPT
Take RYDAPT exactly as your health care provider tells you
Your healthcare provider may prescribe medicines to help prevent the nausea and vomiting during treatment with RYDAPT.
If you miss a dose of RYDAPT, take your next dose at your scheduled time. Do not take an extra dose to make up for a missed dose
Do not open or crush RYDAPT capsules
If you vomit after taking a dose of RYDAPT, do not take an extra dose. Take your next dose at your scheduled time.